MERLN is a growing institute and new positions are frequently available. Prospective PhD candidates and postdoctoral researchers are encouraged to apply for open vacancies. For international candidates, it is noteworthy that it is the norm in the Netherlands to directly apply for a PhD position as it becomes advertised. This is in contrast with some countries (e.g., US, Canada, UK) where you apply to a University or Graduate School with a set annual deadline. If you are interested in performing your doctoral research at MERLN, you should search for an open vacancy and apply before the deadline closes. Keep an eye on this page and Academic Transfer website for the latest vacancies.

Our Principal Investigators (PIs) also welcome open applications from outstanding candidates at any time. Please submit your CV and cover letter to the PI of interest by email.

PhD Candidate Bioengineering Autonomic Innervation & Optogenetic Control in 3D Tissue Models

Help us build the first optogenetically controllable model of sympathetic innervation in engineered 3D tissue, combining stem cell biology, genetic engineering, and advanced imaging. In this PhD project, you will establish iPSC-derived sympathetic neurons within 3D hydrogel-based tissue models and develop electrophysiological recordings to achieve a functional, label-free readout of neuronal activity. Alongside this, you will apply genetic engineering to introduce optogenetic tools, creating complementary optical approaches for stimulation and readout within the same 3D environment.

• Our goal: The aim of this PhD project is to develop integrated 3D tissue models by combining iPSC-derived sympathetic neurons with hydrogel-based systems, and to establish functional, label-free readouts of neuronal activity using electrophysiological and optogenetic approaches.
• Your colleagues: This position is embedded within our research group (Neural Engineering), part of the Faculty of Health, Medicine and Life Sciences, which focuses on tissue innervation and combines biofabrication, stem cell biology, genetic engineering, and advanced imaging to build physiologically representative in vitro models of the peripheral and autonomic nervous system. You will work closely with the PI and collaborate with colleagues across cell biology, bioengineering, and imaging within the group.

Would you like to know more about the vacancy? Please read the full vancancy here.

Closing date: 15-09-2026